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本文以定点记录大鼠胃和十二指肠运动的方法,观察侧脑室内注射(i.c.v.)微量γ-氨基丁酸(GABA)对胃和十二指肠运动的影响,发现GABA能显著增强胃和十二指肠运动。一叶萩碱(i.c.v.)、阿托品(i.H.)或切断膈下迷走神经,均可完全阻断这一增强效应 而该效应却不受酚妥拉明(i.c.v.或i.m.)、心得安(i.c.v.或i.m.)或阿托品(i.c.v.)的影响,提示GABA在脑内可能刺激中枢内与调节胃肠运动有关的神经核团,经迷走神经使胃肠运动增强。
In this study, gastric and duodenal movements in rats were recorded at fixed points, and the effects of intracerebro-ventricular injection (icv) of trace amounts of gamma-aminobutyric acid (GABA) on gastric and duodenal movements were observed. It was found that GABA can significantly enhance the stomach. And duodenum exercise. A mycophylline (icv), atropine (iH), or severing of the infraorbital vagus nerve can completely block this potentiation but this effect is not affected by phentolamine (icv or im), propranolol (icv or im) The effect of atropine (icv) suggests that GABA may stimulate the nucleus in the brain that is involved in the regulation of gastrointestinal motility in the brain and that vagal nerves enhance gastrointestinal motility.