黑棘皮症(Acanthosis nigricans)是一种以色素沉着为主要表现的皮肤疾病,几乎所有的患者均伴有恶性肿瘤,大多为消化道肿瘤。现本文报道1例罕见的黑棘皮症合并肢端肥大。 患者,男性,61岁。1983年10月起头面部、躯干和四肢皮肤渐变黑,尤以皮肤皱折处和腋窝、腹股沟、脐周为最明显。1984年活检诊断为黑棘皮症。当时无任何消化道症状,胃镜活检示胃窦慢性萎缩性胃炎、重度肠腺化生和轻度不典型增生。随后出现 Acanthosis nigricans is a skin disease characterized by pigmentation. Almost all patients are accompanied by malignant tumors, and most of them are digestive tract tumors. This article reports one case of rare acanthosis with acromegaly. Patient, male, 61 years old. In October 1983, the skin on the face, trunk, and extremities began to darken, especially in skin creases, and in the armpits, groin, and umbilical cord. Biopsy was diagnosed as acanthosis in 1984. At the time, there were no gastrointestinal symptoms. A gastroscope biopsy showed chronic atrophic gastritis of the gastric antrum, severe intestinal metaplasia, and mild dysplasia. Then appeared