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目的:检测并分析蛋白4.1R基因敲除小鼠(4.1R-/-)和野生型小鼠(4.1R+/+)血液生理生化参数。方法:摘眼球法采集两组小鼠(n=6)血液,用全自动血液细胞分析仪和生化分析仪检测血液生理生化参数。结果:血液生理参数中,4.1R-/-小鼠红细胞计数、血红蛋白、红细胞压积和中性粒细胞比率显著低于野生型小鼠(P<0.05);血小板计数、平均血小板体积、血小板压积、白细胞计数、淋巴细胞比率显著高于野生型小鼠(P<0.05)。生化参数中,4.1R-/-小鼠碱性磷酸酶显著低于野生型小鼠,总胆红素、直接胆红素和间接胆红素显著高于野生型小鼠(P<0.05)。结论:蛋白4.1R缺失可导致慢性溶血性贫血,4.1R-/-小鼠相关血液生理生化参数随之改变。
Objective: To detect and analyze the blood physiological and biochemical parameters of 4.1R gene knockout mice (4.1R - / -) and wild type mice (4.1R + / +). Methods: Blood was collected from two groups of mice (n = 6) by eyeball method, and the blood physiological and biochemical parameters were detected by automatic blood cell analyzer and biochemical analyzer. Results: In the blood physiological parameters, the erythrocyte count, hemoglobin, hematocrit and neutrophil ratio in 4.1R - / - mice were significantly lower than those in wild type mice (P <0.05). The platelet count, mean platelet volume, platelet pressure Product, white blood cell count, lymphocyte ratio was significantly higher than wild-type mice (P <0.05). The biochemical parameters of 4.1R - / - mice alkaline phosphatase were significantly lower than wild type mice, total bilirubin, direct bilirubin and indirect bilirubin significantly higher than wild-type mice (P <0.05). CONCLUSION: The lack of protein 4.1R can lead to chronic hemolytic anemia. The blood physiological and biochemical parameters of 4.1R - / - mice change accordingly.