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用家冤体温法检查热原,需要一定条件的试验动物,操作也较麻烦费时。近几年来,国内有不少单位进行了四溴酚酞乙醋法检查热原的研究,希望能代替体温法应用于实际工作。过去一段时期对这种方法的评价并不完全一致,但最近的一些试验报导(见本刊9卷4期第185贾孙玉林等著《关于用四溴酚酞乙酯钾(T.B.P.)检查热原的探讨》本支)表明,四溴酚酞乙酯法灵敏度差,因此在检验工作中还不能用以代替药典的方法。
Check the pyrogen with the body temperature method, the test animals need certain conditions, the operation is more cumbersome and time-consuming. In recent years, many units in China have carried out the investigation of pyrogen by tetrabromophenolphthalein and ethyl acetate method, hoping to replace the body temperature method used in practical work. The evaluation of this method has not been entirely consistent in the past period, but recent experiments have reported (see Article 9, Issue 4, Page 185 of the same paper). Sun Yulin et al., “About the Examination of Pyrogen with Potassium Tetrabromophenolphthalate (TBP) Of the discussion ”this branch) shows that tetrabromophenolphthalein ethyl ester sensitivity is poor, so the test can not be used in place of pharmacopoeial methods.