缝隙连接(gap junction,GJ)是细胞间直接进行信息交换的重要通道,由其介导的通讯方式缝隙连接细胞间通讯(gap junction intercellular communication,GJIC)在细胞的新陈代谢、内环境稳定、增殖和分化等生理过程中发挥着关键的调节作用[1]。顺铂是临床治疗肿瘤中广泛应用的化疗药物之一,但是肿瘤细胞对顺铂产生耐药性明显降低顺铂的疗效, Gap junction (GJ) is an important channel for the direct exchange of information between cells. GJIC, a cell-cell communication mechanism mediated by GJIC, plays an important role in cell metabolism, homeostasis, Differentiation and other physiological processes play a key regulatory role [1]. Cisplatin is one of the widely used chemotherapeutic drugs in clinical treatment of tumors, but the drug resistance of tumor cells to cisplatin significantly reduces the efficacy of cisplatin,