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目的:分析贵州省各级地方性砷中毒（简称地砷病）实验室网络运行及外质控考核情况，为评价地砷病防治效果以及采取针对性干预措施提供可靠的实验质量保障。方法:对2008-2017年贵州省各级地砷病实验室网络运行及外质控考核结果（水砷、尿砷）进行统计学分析。考核范围包括省、市、县3级承担地砷病监测任务的砷检测实验室（省、市级各1个，县级2个）。结果:2008-2017年，1个省级水砷、尿砷测定实验室考核均合格；1个市级实验室2011-2017年水砷、尿砷考核均合格；2个县级实验室2014-2017年水砷、尿砷考核均合格。2014-2017年省、市、县3级实验室水砷、尿砷考核连续全部合格。省级实验室水砷2008-2017年、尿砷2009-2017年，│Z│值均≤2，考核均为合格，所得结果满意；市级和1个县级实验室在2010年后水砷、2011年后尿砷的│Z│值也均≤2，考核均为合格，所得结果满意。结论:贵州省地砷病实验室网络运行状况良好，实验室质量控制及砷样品外质控考核结果符合国家实验室质量要求，可为持续消除地砷病提供准确、可靠的检测数据保障。“,”Objective:This paper analyzed the operation of network laboratory and external quality control assessment of endemic arsenic disease laboratories at all levels in Guizhou Province, to provide reliable experimental quality assurance for evaluating the prevention and treatment effect and taking targeted intervention measure of endemic arsenic poisoning.Methods:The results of network operation and external quality control (arsenic in water, arsenic in urine) were statistically analyzed from 2008 to 2017. The assessment scope included the arsenic detection laboratory of provincial (1), municipal (1) and county level (2) which undertook endemic arsenic poisoning monitoring tasks.Results:From 2008 to 2017, 1 provincial laboratory for the determination of arsenic in water and urine was qualified. From 2011 to 2017, 1 municipal laboratory for the determination of arsenic in water and urine was qualified. From 2014 to 2017, 2 county level laboratories for the determination of arsenic in water and urine were qualified. From 2014 to 2017, the water and urinary arsenic in provincial, municipal and county laboratories had been continuously assessed as all qualified. The │Z│ values of water arsenic in provincial laboratories from 2008 to 2017 and urine arsenic from 2009 to 2017 were ≤2, and the results were satisfactory. The │Z│ values of arsenic in water after 2010 and in urine after 2011 in municipal and one county level laboratories were ≤2, which were all qualified and the results were satisfactory.Conclusions:The network laboratory of endemic arsenic disease in Guizhou Province operates well. The quality control of the laboratory and the results of external quality control of arsenic samples meet the quality requirements of the national laboratory, which can provide accurate and reliable test data guarantee for the continuous elimination of endemic arsenic disease.