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目的探讨姜黄素（curcumin，Cur）对人癌细胞株的体外作用特点及其水溶液的稳定性。方法以MTT法观察对人胃癌MGC803、人肝癌Be17402、人红白血病K562及其耐阿霉素株K562／ADM等的体外杀伤作用，并以体外活性变化为指标观察Cur水溶液的稳定性。结果Cur8.5～136.0μmol·L-1对上述细胞的IC50分别为13.0，15.9，11.7，62.6μmol·L-1;低于8.5μmol·L-1就能完全对抗41.5nmol·L-1表皮生长因子（EGF）的促增殖作用。Cur水溶液于4℃贮存3～7d体外抗癌活性明显下降。结论Cur对MGC803、Be17402、K562等有明显的杀伤作用，并能对抗EGF的促增殖作用，其水溶液稳定性较差。
Objective To investigate the in vitro effects of curcumin (Cur) on human cancer cell lines and the stability of aqueous solution. Methods MTT assay was used to observe the killing effect of human gastric cancer MGC803, human hepatoma Be17402, human leukemia K562 and its adriamycin-resistant K562/ADM in vitro, and the stability of Cur aqueous solution was observed with changes in in vitro activity. Results The IC50 of Cur8.5～136.0μmol·L-1 for these cells were 13.0,15.9,11.7,62.6μmol·L-1, respectively; below 8.5μmol·L-1, it completely against 41.5 nmol·L-1 epidermis. Growth factor (EGF) promotes proliferation. The curcumin aqueous solution stored at 4°C for 3 to 7 days significantly reduced the in vitro anticancer activity. Conclusion Cur has obvious killing effect on MGC803, Be17402, K562, etc., and can resist the proliferative effect of EGF, and its aqueous solution stability is poor.