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目的观察丹红注射液联合低分子肝素治疗不稳定型心绞痛(UAP)的临床疗效。方法79例UAP患者分为两组,治疗组40例,对照组39例。治疗组在常规治疗的基础上采用丹红注射液静脉滴注联合皮下注射低分子肝素。对照组仅行常规治疗。两组疗程均为7d。治疗前后观察心绞痛发作次数、心电图ST段变化,监测血小板、凝血酶原时间(PT),激活部分凝血活酶时间(APTT)。结果两组均能明显控制心绞痛的发作次数(P<0.05),但治疗组更能显著降低心绞痛的发作(与对照组比较,P<0.05)。治疗前后治疗组血小板、PT、APTT无显著变化。结论丹红注射液联合低分子肝素是治疗UAP的一种安全、有效的方法。
Objective To observe the clinical efficacy of Danhong injection combined with low molecular weight heparin in the treatment of unstable angina pectoris (UAP). Methods 79 cases of UAP patients were divided into two groups, treatment group 40 cases, control group 39 cases. On the basis of routine treatment, the treatment group received intravenous infusion of Danhong injection and subcutaneous injection of low molecular weight heparin. Control group only routine treatment. Two courses of treatment are 7d. Before and after treatment, the number of episodes of angina pectoris, ST segment changes in electrocardiogram, platelet count, prothrombin time (PT) and APTT were monitored. Results Both groups were able to significantly control the number of angina attacks (P <0.05), but the treatment group could significantly reduce the incidence of angina pectoris (P <0.05 compared with the control group). Before and after treatment, there was no significant change of platelet, PT, APTT in the treatment group. Conclusion Danhong injection combined with low molecular weight heparin is a safe and effective method for the treatment of UAP.