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以叶绿素-a(b)的最初降解产物脱镁叶绿酸-a(b)甲酯为起始原料,利用其二氢卟吩周环上的活性反应区域,经羟醛缩合、空气氧化和氧化剂氧化等常见的化学反应构建羟甲基或者甲酰基结构,再通过Grignard反应、酸催化脱水和E-环重排反应,在周环的不同位置上引进了具有较高反应活性的甲烯基或者乙烯基,完成了一系列未见报道的多端烯基取代的叶绿素类二氢卟吩衍生物的合成,其化学结构均经UV、IR、~1H NMR及元素分析予以证实;对相应的化学反应提出了可能的反应机理,并对部分新化合物的体外光动力抗菌活性进行了测试.
Using the pheophorbide-a (b) methyl ester as the initial degradation product of chlorophyll-a (b) as a starting material, the active reaction region on the chlorin ring was oxidized by aldol condensation, air oxidation and Oxidant oxidation and other common chemical reactions to build methylol or formyl structure, and then through the Grignard reaction, acid-catalyzed dehydration and E-ring rearrangement reaction in the circumferential ring at different positions to introduce a higher reactivity of the vinyl Or vinyl group, a series of unreported terminal alkenyl-substituted chlorophyllin chlorin derivatives were synthesized. Their chemical structures were confirmed by UV, IR, ~ 1H NMR and elemental analysis. For the corresponding chemical The reaction proposed a possible reaction mechanism, and some of the new compounds in vitro photodynamic antibacterial activity were tested.