We prove that there do not exist quasi-isometric embeddings of connected nonabelian nilpotent Lie groups equipped with left invariant Riemannian metrics into a metric measure space satisfying the curvaturedimension condition RCD(0,N) with N ∈ R and N ＞ 1.In fact,we can prove that a sub-Riemannian manifold whose generic degree of nonholonomy is not smaller than 2 cannot be bi-Lipschitzly embedded in any Banach space with the Radon-Nikodym property.We also get that every regular sub-Riemannian manifold do not satisfy the curvature-dimension condition CD(K,N),where K,N ∈ R and N ＞ 1.Along the way to the proofs,we show that the minimal weak upper gradient and the horizontal gradient coincide on the Cot-Carathéodory spaces which may have independent interests.