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本文应用高效液相色谱法分析34例胃癌病人尿多胺含量,并与19例胃良性溃疡病人及23名正常人对比。结果表明胃癌病人尿多胺含量明显高于胃良性溃疡病人和正常人。有淋巴结转移和肝转移的胃癌病人尿多胺含量明显高于无淋巴结转移和肝转移的胃癌病人。胃癌根治切除术后病人尿多胺含量比术前明显降低。尿多胺含量与胃癌病理分化程度无明显关系。我们认为尿多胺含量测定对胃癌辅助诊断,术前预测肿瘤转移及监测治疗效果有一定的临床意义。
In this paper, urinary polyamine content in 34 patients with gastric cancer was analyzed by high performance liquid chromatography and compared with 19 patients with benign gastric ulcer and 23 normal controls. The results showed that the content of urinary polyamines in gastric cancer patients was significantly higher than that in patients with benign ulcers and normal controls. The urinary polyamine content in gastric cancer patients with lymph node metastasis and liver metastasis was significantly higher than that in gastric cancer patients without lymph node metastasis and liver metastasis. The urinary polyamine content in patients after radical gastrectomy was significantly lower than before surgery. Urinary polyamine content had no significant relationship with the degree of pathological differentiation of gastric cancer. We believe that determination of urinary polyamine content has certain clinical significance for the diagnosis of gastric cancer, predicting tumor metastasis before surgery, and monitoring the therapeutic effect.