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目的:本文旨在研究口服抗凝剂治疗的患者,其有不同程度外科创伤和不同强度抗凝剂时纤维蛋白密封剂对其口腔手术的影响。研究设计:连续系列69例患者口服抗凝剂治疗、进行口腔手术而未改变抗凝剂强度者方被推荐。记录每一病人抗凝剂适应症,治疗日的国际正常比值(低,1.0-2.0;中,2.1-3.0;高,3.1-5.0),外科创伤程度(分1-12类)及并发症,以及其相互关系。结果:心瓣膜修复病人32例(46.4％),房纤维性颤动和风湿性或局部缺血性心脏病病人23例(33.3％),和从前患过血栓栓塞病病人14例(20.3％)。20例(29％)为低强度抗凝(国际正常比值1.0-2.0),26例(37.7％)为中强度抗凝(国际正常
Objectives: This study aimed to investigate the effects of oral fibrin sealants on oral surgery in patients undergoing oral anticoagulation therapy with varying degrees of surgical trauma and different intensities of anticoagulants. Study Design: A continuous series of 69 patients treated with oral anticoagulants, oral surgery without change in strength of anticoagulants were recommended. The international normal ratios (low, 1.0-2.0; medium, 2.1-3.0; high, 3.1-5.0), surgical trauma (grades 1-12) and complications were recorded for each patient in terms of anticoagulant indications, As well as their interrelationships. RESULTS: Thirty-two patients (46.4%) had cardiac valve repair, 23 (33.3%) had atrial fibrillation and rheumatic or ischemic heart disease, and 14 (20.3%) had previous thromboembolic disease. Twenty patients (29%) had low-intensity anticoagulation (international normal ratio 1.0-2.0) and 26 patients (37.7%) were moderate-intensity anticoagulant