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目的:探讨前列腺孤立性肿瘤的临床表现、病理形态学、免疫组化及生物学行为。方法:收集前列腺孤立性纤维肿瘤15例,观察其临床病理特点及免疫组化表型。结果:年龄46～91岁,平均54.5岁。光学显微镜下形态多样,边界清晰,由交替性分布的细胞丰富区和细胞稀疏区组成,分技状的血管外皮瘤样结构;可见黏液变、脂肪细胞形成。免疫表型:几乎所有肿瘤细胞质呈Viment(15/15)、CD34(15/15)强阳性、弥漫表达,CD99(14/15)、Bcl-2(13/15)呈阳性表达。结论:孤立性纤维肿瘤可发生在躯体所有解剖部位,发生在前列腺的孤立性纤维肿需与该处其它梭形细胞肿瘤鉴别诊断,依据其组织学特点及免疫组化表型可作出诊断。
Objective: To investigate the clinical manifestation, histopathology, immunohistochemistry and biological behavior of prostate solitary tumor. Methods: Fifteen cases of prostatic solitary fibrous tumor were collected. The clinicopathological features and immunohistochemical phenotypes were observed. Results: Aged 46-91 years, mean 54.5 years old. Under the light microscope, the morphology is diverse and the boundary is clear. It consists of alternatingly-distributed cell-rich areas and sparsely-populated cells, and is characterized by an arteriolar neoplasia-like structure. Visible mucus changes and adipocyte formation. Immunophenotype: Almost all tumor cytoplasm showed Viment (15/15), CD34 (15/15) strong positive, diffuse expression, CD99 (14/15), Bcl-2 (13/15) positive expression. Conclusion: Solitary fibrous tumor can occur in all anatomical parts of the body. Solitary fibroids in the prostate need to be differentiated from other spindle cell tumors in the area. Based on their histological features and immunohistochemical phenotype, they can be diagnosed.