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目的探讨新生儿肠道病毒感染的高危因素。方法选择我院2009年5月至2011年5月收治的新生儿肠道病毒感染的患儿60例,对其临床资料进行回顾性分析。结果 30例血肌酶中LDHHBDH增高;28例中性粒细胞<50%,32例>50%;19例白细胞数为(6.5～10.0)×109/L,41例为(10.1-25.0)×109/L。均采取综合治疗,脑脊液异常的患儿治疗5d后进行复查,脑脊液蛋白及细胞数均下降,7d后呈正常恢复,均痊愈出院,随访无异常情况发生,因多器官功能衰竭在治疗5d后死亡1例。结论故临床需对新生儿肠道病毒感染进行早期明确诊断,及时治疗,避免暴发流行,一旦有医院感染迹象,应采取有效隔离,切断传播途径,加强相关检查,针对高危因素制定防控措施,以降低发病率,提高患儿生存质量。
Objective To investigate the risk factors of neonatal enterovirus infection. Methods Sixty children with neonatal enterovirus infection from May 2009 to May 2011 in our hospital were selected and their clinical data were retrospectively analyzed. Results Serum LDH and HBDH increased in 30 patients. The number of neutrophils in 28 patients was lower than 50% (32 cases), the number of leukocytes in 19 patients was (6.5-10.0) × 109 / L, while that in 41 patients was (10.1-25.0) × 109 / L. All children with cerebrospinal fluid abnormalities were examined after 5 days of treatment. The protein and cell number of cerebrospinal fluid decreased, and recovered after 7 days. All patients were cured and discharged without any abnormality. Multiple organ failure occurred after 5 days of treatment 1 case. Conclusion The clinical diagnosis of neonatal enterovirus infection needs early and definite diagnosis, timely treatment and avoid outbreak. In case of signs of nosocomial infection, it should be effectively isolated and cut off the route of transmission, to strengthen the relevant inspection, to develop prevention and control measures for risk factors, To reduce the incidence and improve the quality of life of children.