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同部抗菌药物能有效地防治烧伤创面侵袭性感染。目前临床应用最多的是磺胺嘧啶银,但其穿透焦痂的能力较差。体外实验显示,磷霉素对绿脓杆菌具有良好的抗菌活性,且分子量小,易于弥散入组织。为探讨磷霉素钙应用于烧伤创面的可能性,我们测定了焦痂下磷霉素钙的浓度,并对其在烧伤创面的抗绿脓杆菌效果进行观察。
The same department of antibacterial drugs can effectively prevent and treat invasive wound infection. Currently the most clinically used silver sulfadiazine, but its ability to penetrate the eschar is poor. In vitro experiments show that fosfomycin Pseudomonas aeruginosa has good antibacterial activity, and the molecular weight is small, easy to diffuse into the tissue. To investigate the possibility of applying fosfomycin calcium to burn wounds, we measured the concentration of fosfomycin calcium in the eschar and observed the anti-Pseudomonas aeruginosa effect on burn wounds.