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醋酸甲地孕酮(MA)是一种高效黄体避孕药。本文报告以紫外254nm波长检测的反相高效液相色谱法,测定家兔血浆中MA浓度及其药物动力学参数,并应用于临床人血浆中MA浓度监测。色谱条件:柱YWG-C_(18)H_(37)(10μm,15cm×5mml·D);用梯度洗脱法选择甲醇-水二元恒溶剂流动相,其组成预期值为:MeOH-H_2O(73:27)。分析过程:以醋酸炔诺酮为内标,用乙酸乙酯提
Megestrol acetate (MA) is a highly effective progestin contraceptive. In this paper, reversed-phase high performance liquid chromatography (UV-254 nm) was used to determine the concentration of MA and its pharmacokinetic parameters in rabbit plasma and to monitor the concentration of MA in clinical human plasma. Chromatographic conditions: column YWG-C 18 H 37 (10μm, 15cm × 5mml · D); using a gradient elution method methanol - water binary constant solvent mobile phase, the composition of the expected value: MeOH-H_2O 73:27). Analysis process: norethisterone acetate as an internal standard, with ethyl acetate