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目的对海洋真菌Aspergillus sp.SCS-KFD03的发酵液中化学成分进行分离鉴定,并测定其生物活性。方法采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱和高效液相色谱等技术进行分离纯化,运用各种波谱方法对分离所得化合物进行结构鉴定,并测定化合物乙酰胆碱酯酶和α-糖苷酶抑制活性。结果分离鉴定了9个化合物,经鉴定为phomaligol A1(1)、5-(乙酰氧基甲基)呋喃-3-酸(2)、phomapyrone C(3)、4-羟基异苯并呋喃-1(3H)-酮(4)、penicillivinacine(5)、22(E)-5α,8α-epidioxyergosta-6,22-dien-3β-ol(6)、lucidal(7)、dankasterone A(8)、bis-(2-methylheptyl)-phthalate(9),其中化合物4为新天然产物。化合物5、6、7和9具有较弱的乙酰胆碱酯酶抑制的活性,化合物5具有强于阳性药阿卡波糖的α-糖苷酶抑制活性,8和9的α-糖苷酶抑制活性与阳性药相当。结论化合物1~9均为首次从海洋曲霉属真菌Aspergillus sp.SCS-KFD03中分离得到,部分化合物具有乙酰胆碱酯酶和α-糖苷酶的抑制活性。
OBJECTIVE To isolate and identify the chemical constituents from the fermentation broth of marine fungus Aspergillus sp. SCS-KFD03 and determine its biological activity. Methods The compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20 column chromatography and high performance liquid chromatography (HPLC). The structures of the isolated compounds were identified by various spectral methods. The inhibitory activities of compounds acetylcholinesterase and α-glucosidase active. Results Nine compounds were identified and identified as phomaligol A1 (1), 5- (acetoxymethyl) furan-3-acid (2), phomapyrone C (3), 4-hydroxyisobenzofuran- Penicillivinacine (5), 22 (E) -5α, 8α-epidioxyergosta-6,22-dien-3β-ol (6), lucidal (7), dankasterone A (8), bis - (2-methylheptyl) -phthalate (9), of which compound 4 is a new natural product. Compounds 5, 6, 7, and 9 have a weaker acetylcholinesterase inhibitory activity, Compound 5 has a stronger α-glucosidase inhibitory activity than the positive drug acarbose, and α-glycosidase inhibitory activities of 8 and 9 are positive The medicine is quite Conclusion Compounds 1 to 9 were isolated from Aspergillus sp. SCS-KFD03 for the first time, and some compounds exhibited inhibitory activity against acetylcholinesterase and α-glucosidase.