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目的比较不同年龄组宫颈癌患者FIGO分期和术后临床病理特征。方法对四川大学华西第二医院2005年11月至2010年4月手术治疗的1543例宫颈癌患者资料进行回顾性分析。结果患者发病年龄为17～75岁,中位年龄42.0岁。近5年来年轻宫颈癌患者多为FIGO早期,≤35岁组FIGOⅠA1～ⅠB2所占比例高于>35岁组;≤35岁组瘤体直径≥4cm的所占比例高于>35岁组。术后组织学分类仍以鳞癌为主,非鳞癌所占比例较少。≤35岁组宫颈间质深浸润所占比例低于>35岁组,而其余高危病理因素在不同年龄组间差异无统计学意义。术前FIGO分期与术后高危病理因素存在一定的正相关性,多因素分析显示间质浸润深度、宫旁浸润、盆腔淋巴结转移、年龄与FIGO分期的关系更值得关注。结论重视对宫颈腺癌以及中老年宫颈癌患者早期筛查和诊治。术前FIGO分期越晚预示着术后出现高危病理因素的风险越高,注意年龄、间质浸润深度、盆腔淋巴结转移、宫旁浸润这些因素与FIGO分期的关系,对选择恰当的治疗方式、提高患者的生活质量、改善预后以及降低死亡率具有重要意义。
Objective To compare the clinical and pathological features of FIGO stage and postoperative patients with cervical cancer in different age groups. Methods The data of 1543 cervical cancer patients who underwent surgery in Huaxi Second Hospital of Sichuan University from November 2005 to April 2010 were retrospectively analyzed. Results The age of onset was 17-75 years, with a median age of 42.0 years. In the recent 5 years, young patients with cervical cancer were mostly early FIGO. The proportion of FIGOⅠA1-ⅠB2 in ≤35 years old group was higher than that in> 35 years old group. The proportion of patients with ≤4 cm in ≤35 years old group was higher than that in> 35 years old group. Squamous cell carcinoma was still the main histological classification, and the proportion of non-squamous cell carcinoma was less. The proportion of deep cervical interstitial infiltration in ≤35 years old group was lower than that in> 35 years old group, while the other high risk pathological factors had no statistical significance in different age groups. There was a positive correlation between the preoperative FIGO stage and postoperative high risk pathological factors. Multivariate analysis showed that the relationship between the depth of interstitial infiltration, uterine infiltration, pelvic lymph node metastasis, age and FIGO stage was more worthy of attention. Conclusion The importance of early screening and diagnosis and treatment of cervical adenocarcinoma and middle-aged and elderly cervical cancer patients. The higher the preoperative FIGO stage, the higher the risk of postoperative high-risk pathological factors. Pay attention to the relationship between age, interstitial infiltration depth, pelvic lymph node metastasis and uterine infiltration, and FIGO staging, and select the appropriate treatment to improve The quality of life of patients, improving prognosis and reducing mortality are of great importance.