血小板减少是临床上常见的血液异常表现,严重者可广泛出血,以致死亡。其原因为:①血小板生成不够;②破坏增多;③血小板在脾的滞留。初步诊断不难,如生成低下者可见骨髓巨核细胞减少或消失及成熟障碍;破坏增多者巨核细胞增多或正常;滞留于脾者多有脾脏增大。但要确定其病因和机理并非容易,尤其是由于免疫异常所致。自从1975年Dixon等报道用定量抗球蛋白消耗试验在体外测定PAIgG,指出特发性血小板减少性紫癜(ITP)患者明显升高以来,国内外学者利用各种免疫学方法,普遍开展了血小板相关免疫球蛋白(PAIg)特别是PAIgG的测定。这对ITP Thrombocytopenia is a common clinical manifestations of blood abnormalities, severe cases can be extensive bleeding, resulting in death. The reason is: ① platelet production is not enough; ② damage increased; ③ platelet retention in the spleen. The initial diagnosis is not difficult, such as the formation of low visible bone marrow megakaryocytes decreased or disappeared and maturation; increased destruction of megakaryocytes increased or normal; spleen retention in spleen increased. But to determine the etiology and mechanism is not easy, especially due to immune abnormalities. Since 1975, when Dixon et al. Reported that PAIgG was determined in vitro by quantitative antiglobulin depletion test and pointed out that patients with idiopathic thrombocytopenic purpura (ITP) were significantly increased, scholars at home and abroad used various immunological methods to carry out platelet-related Determination of immunoglobulin (PAIg), especially PAIgG. This is for ITP