目的:探讨抗感染治疗联合激素雾化治疗应用于小儿肺炎治疗对体内的肿瘤坏死因子α(TNF-α)、白介素-6(IL-6)及白介素-8(IL-8)的影响。方法:选取2012年1月~2013年12月该院儿科收治的130例肺炎患儿,将其随机分为观察组以及对照组,每组65例,其中观察组给予抗感染联合普米克令舒雾化吸入治疗,对照组仅给予普米克令舒雾化吸入治疗,比较两组的治疗效果以及相关指标的变化情况。结果:观察组的治疗有效率为95.38%(62/65),对照组为76.92%(50/65),两组比较,差异有统计学意义(χ2=9.286,P<0.05)。治疗后两组患儿的TNF-α、IL-6、IL-8水平均较治疗前明显下降,而观察组明显低于对照组,治疗后两组临床症状评分均较治疗前显著下降,且观察组治疗后下降更明显,两组比较,差异有统计学意义(P<0.05)。结论:头孢曲松抗感染联合激素雾化治疗能够显著降低机体炎性细胞因子的表达水平,缓解临床症状,提高治疗效果。 Objective: To investigate the effects of anti-infective therapy combined with hormone nebulization on tumor necrosis factor α (TNF-α), interleukin-6 (IL-6) and interleukin-8 (IL-8) in children with pneumonia. Methods: A total of 130 children with pneumonia admitted to our hospital from January 2012 to December 2013 were randomly divided into observation group and control group, with 65 cases in each group. The observation group was given anti-infection combined with pulmicort Atomization inhalation treatment, the control group was given Pulmicort Respiratory spray inhalation alone, the treatment effect of the two groups and the changes of related indicators were compared. Results: The effective rate was 95.38% (62/65) in the observation group and 76.92% (50/65) in the control group. The difference between the two groups was statistically significant (χ2 = 9.286, P <0.05). After treatment, the levels of TNF-α, IL-6 and IL-8 in both groups were significantly lower than those before treatment, while the observation group was significantly lower than that of the control group. After treatment, the clinical symptom scores of both groups decreased significantly The observation group decreased more obviously after treatment, the difference between the two groups was statistically significant (P <0.05). Conclusion: Ceftriaxone anti-infective combined with hormone atomization treatment can significantly reduce the expression of inflammatory cytokines, relieve clinical symptoms and improve the therapeutic effect.