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PCL-PEG-PCL聚合物具有较好的生物相容性,同时又是很好的可降解材料,用作人体内生物材料时,由于合成过程中所使用具有毒性的催化剂很难完全除掉,亲水性不好,使得其在医学领域的应用受到限制。本研究率先采用无毒NaH为催化剂,具有亲水性、生物相容性的聚乙二醇(PEG)与聚ε-己内酯(PCL)为原料,发生共聚反应,控制单体己内酯与聚乙二醇的加入比例,合成出不同聚合度的高亲水性的PCL-PEG-PCL聚合物,探究了温度、催化剂与单体加入比例对反应的影响。通过GPC、XRD和DSC、TGA对其进行分析检测和表征,揭示其内部结构和规律性。
PCL-PEG-PCL polymer has good biocompatibility, but also is a good biodegradable material, when used as a biomaterial in human body, it is difficult to completely remove the toxic catalyst used in the synthesis process, Poor hydrophilicity, making its application in the medical field is limited. In this study, the first use of non-toxic NaH as a catalyst, with hydrophilic, biocompatible polyethylene glycol (PEG) and poly-ε-caprolactone (PCL) as raw materials, copolymerization reaction, control monomer caprolactone With the addition ratio of polyethylene glycol, PCL-PEG-PCL polymer with high degree of polymerization and high degree of polymerization were synthesized. The effects of temperature, ratio of catalyst to monomer on the reaction were investigated. By GPC, XRD and DSC, TGA analysis of its detection and characterization revealed its internal structure and regularity.