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糖血红蛋白(GHb 或 HbA_1是血红蛋白β链 N-末端缬氨酸连接有己糖基,这是成人血红蛋白中少量的正常成份。糖尿病患者血糖浓度升高可导致 GHb 量增加。血红蛋白的糖化经两步非酶促化学反应形成。第一步,葡萄糖和血红蛋白形成不稳定的醛亚胺键(Aldimine linkage),当血糖浓度降低时它便解离。第二步是不稳定的醛亚胺经 Amad-ori 重排形成一稳定的氨基酮键(Ketoamine
Glycohemoglobin (GHb or HbA_1 is a hexosyl group linked to the N-terminal valine of the hemoglobin β chain, which is a small amount of normal components in adult hemoglobin. Increased blood glucose levels in diabetic patients lead to an increase in the amount of GHb. The first step, glucose and hemoglobin form unstable aldimine linkage (Aldimine linkage), when the blood glucose concentration decreases when it dissociates.The second step is unstable aldimine by Amad-ori Rearrangement to form a stable aminoketone bond (Ketoamine