25例未经治疗的肺小细胞癌患者,使用环磷酰胺160—200mg/kg治疗(伴用自体骨髓支持疗法),然后对肺部原发灶及纵隔区进行放射治疗(4,000CGY,亦即4,000 cent-igray,4,000拉得)。放疗后至复发前未经其它治疗。在放疗后至少4个月时19例已可进行评价,其中的15例(70％)有肺纤维化的放射学证据(内14例亦即74％出现症状)。肺纤维化开始发生时间与照射肺部的体积有 Twenty-five untreated patients with small cell lung cancer were treated with cyclophosphamide 160-200 mg/kg (with autologous bone marrow support) and then treated with radiation in the primary lung and mediastinal area (4,000 CGY, that is, 4,000 cent-igray, 4,000 draw). After radiotherapy, there was no other treatment until recurrence. At least 4 months after radiotherapy, 19 cases have been evaluated, and 15 of them (70%) have radiological evidence of pulmonary fibrosis (14 cases, ie, 74%, have symptoms). The time of onset of pulmonary fibrosis and the volume of irradiated lung