论文部分内容阅读
目的:观察氨溴索雾化吸入对放射性肺炎患者血清炎症因子的影响。方法:选择100例放射性肺炎患者为研究对象,随机分为对照组和观察组,对照组给予常规治疗,观察组在常规治疗基础上给予氨溴索雾化吸入。比较两组临床疗效,治疗前及治疗后7 d血清白细胞介素(IL)及其它炎症因子的变化。结果:观察组的总有效率(96.0%)显著高于对照组(P<0.05);两组治疗后血清IL-6、IL-8、IL-10水平均较治疗前明显降低,观察组治疗后血清IL-6、IL-8、IL-10均低于对照组治疗后水平(P<0.05);观察组治疗后血清肿瘤坏死因子-α、超敏C反应蛋白低于治疗前及对照组治疗后水平(P<0.05)。结论:氨溴索雾化吸入能降低放疗性肺炎患者血清炎症因子水平,改善炎症反应状态,对肺损伤有一定保护作用。
Objective: To observe the effect of inhalation of ambroxol on serum inflammatory factors in patients with radiation pneumonitis. Methods: 100 cases of patients with radiation pneumonitis were selected as the research object and randomly divided into control group and observation group. The control group was given routine treatment. The observation group was treated with ambroxol inhalation on the basis of routine treatment. The clinical efficacy, serum interleukin (IL) and other inflammatory factors before and 7 days after treatment were compared between the two groups. Results: The total effective rate (96.0%) in the observation group was significantly higher than that in the control group (P <0.05). The levels of IL-6, IL-8 and IL-10 in the two groups were significantly lower than those before treatment The levels of serum IL-6, IL-8 and IL-10 in serum in the observation group were lower than those in the control group after treatment (P <0.05). The levels of serum tumor necrosis factor-α and high sensitivity C-reactive protein in the observation group were lower than those before treatment and in the control group After treatment level (P <0.05). Conclusion: Inhalation of ambroxol can reduce the levels of serum inflammatory cytokines in patients with radiotherapy pneumonia, improve the inflammatory response status, and have a protective effect on lung injury.