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This paper is to evidence that the antiviral effect of _(ppp)A_(2’p5’)A_(2’p5’)A(2’-5’P_3A_3) could cover a wide spectrum of viruses, the RNA viruses such as influenza H_3N_2/77, influenza H_1N_1/77, ECHO_(11), rhino, Sendai, Sindbis and VSV, and the DNA viruses such as herpes (type Ⅰ). In addition, the antiviral effect of 2’-5’P_3A_3 on ECHO_(11) virus, as compared with other viruses, is more efficient than that of IFN itself. It seems likely that 2’5’P_3A_3 plays an important role in the antiviral action of IFN. After comparing the action of 2’-5’P_3A_3 with interferon (IFN), it has appeared that the action of 2’-5’P_3A_3 is something parallel to that of IFN for most viruses. For a few viruses, however, considerable differences have been observed.
This paper is to evidence that the antiviral effect of ppp A_ (2’p5 ’) A_ (2’p5’) A (2’-5’P_3A_3) could cover a wide spectrum of viruses, the RNA viruses such as influenza H_3N_2 / 77, influenza H_1N_1 / 77, ECHO_ (11), rhino, Sendai, Sindbis and VSV, and the DNA viruses such as herpes (type I). In addition, the antiviral effect of 2’-5’P_3A_3 on ECHO_ (11) virus, as compared with other viruses, is more efficient than that of IFN itself. It seems likely that 2’5’P_3A_3 plays an important role in the antiviral action of IFN. After comparing the action of 2’-5 ’ P_3A_3 with interferon (IFN), it has said that the action of 2’-5’P_3A_3 is something parallel to that of IFN for most viruses. However, there are considerable differences have been observed.