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用放射免疫法测定肝硬化病人的血清Ⅲ型前胶原(PCⅢ)及Ⅳ型胶原(Ⅳ-C)并与正常对照作比较,以探讨PCⅢ、Ⅳ-C与肝硬化的关系。测定的109例中,正常对照38例、肝硬化71例。结果显示:肝硬化病人血清PCⅢ、Ⅳ-C的含量分别为18013±7007μg/L及16251±4415μg/L,明显高于对照组的8800±2103μg/L和9788±1672μg/L,p值均小于001。PCⅢ的异常率为9375%,Ⅳ-C的异常率为9231%,按childpugh分级法,肝硬化病人血清PCⅢ、Ⅳ-C的含量随分级程度的加重其含量也逐步增高,而血清PCⅢ、Ⅳ-C的含量与转氨酶、白蛋白、胆红素含量间无明显相关,提示血清PCⅢ、Ⅳ-C二者对评估肝硬化肝脏的代偿功能是很有价值的
Radioimmunoassay was used to determine the serum levels of type Ⅲ procollagen (Ⅲ) and type Ⅳ collagen (Ⅳ-C) in cirrhotic patients. The levels of PCⅢ, Ⅳ-C and cirrhosis were compared with those of normal controls. Among the 109 cases measured, 38 cases were normal control and 71 cases were cirrhosis. The results showed that the serum levels of PCⅢ and Ⅳ-C in patients with cirrhosis were 18013 ± 7007μg / L and 16251 ± 4415μg / L, respectively, which were significantly higher than those in the control group (8800 ± 2103μg / L and 9788 ± 1672 μg / L, respectively, the p values were less than 001. The abnormal rate of PC Ⅲ was 9375% and the abnormal rate of Ⅳ-C was 9231%. According to the method of childpugh, the content of PCⅢ and Ⅳ-C in patients with cirrhosis increased gradually with the degree of grading , While there was no significant correlation between the levels of PCⅢ and Ⅳ-C in serum and aminotransferase, albumin and bilirubin, which suggested that both PCⅢ and Ⅳ-C were valuable in assessing liver compensatory function of liver cirrhosis