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目的为观察抗血吸虫童虫表膜单克隆抗体与吡喹酮协同杀灭血吸虫的作用。方法用药物加单克隆抗体被动转移小鼠试验，计算小鼠抗攻击感染的减虫率和减卵率。结果在单抗被动转移小鼠感染3d后加吡喹酮组，其减虫率减卵率分别为91.9％和90.3％，均明显高于单用药物组17.2％、26.9％的减虫率和减卵率;在单抗被动转移小鼠感染38d后加吡喹酮组，其减虫率、减卵率分别为96.9％和83.4％，亦明显高于单用药物组84.9％、31.9％的减虫率和减卵率。结论被动转移的单抗与吡喹酮表现为一种明显的协同杀虫减卵作用。宿主免疫水平的高低明显影响吡喹酮的杀虫作用，提高宿主体内特异性抗体水平，可显著加强吡喹酮预防血吸虫感染和杀灭血吸虫的作用。
The purpose is to observe the role of the monoclonal antibody against Schistosoma japonicum Schistosomula surface and praziquantel in combating Schistosoma japonicum. Methods The mice were experimentally transferred with the monoclonal antibody and the drug was used to calculate the worm reduction rate and the oviposition rate. RESULTS: In the mice infected with MA3 negatively infected with praziquantel 3 days after infection, the worm reduction rates were 91.9% and 90.3%, respectively, which were significantly higher than those of the single drug group of 17.2% and 26.9% respectively The rate of oviposition and the reduction of oviposition rate were 96.9% and 83.4% respectively, which were also significantly higher than that of the single drug group (84.9%, 31.9%, respectively) Worm reduction and egg reduction rates. Conclusion Passively transfected mAb and praziquantel exhibit an obvious synergistic insecticidal and ovulation reduction effect. The level of host immunity significantly affects the insecticidal effect of praziquantel and increases the level of specific antibodies in the host body, which can significantly enhance the role of praziquantel in preventing schistosomiasis infection and killing schistosomiasis.