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目的:探讨奥美拉唑、阿莫西林联合甲硝唑治疗幽门螺杆菌性溃疡疗效及安全性。方法:2010年1月～2011年5月收治消化性溃疡患者79例,随机分为两组,治疗组40例和对照组39例,两组在治疗前1周均未接受过铋剂及非甾体类镇痛药物。治疗组应用奥美拉唑20mg,2次/日,早晚1次口服;阿莫西林0.5g,3次/日口服,餐前30分钟服用;甲硝唑0.4g,2次/日,疗程1周。对照组应用兰索拉唑30mg,克拉霉素0.5g,左氧氟沙星0.2g,均2次/日,疗程1周。结果:两组经过4周的治疗,治疗组40例中尿素酶依赖试验和14C呼吸试验阴性37例,Hp根除率为92.5%,对照组39例尿素酶依赖试验和14C呼吸试验阴性34例,Hp根除率为87.2%,治疗组疗效略高于对照组,但两组Hp根除率比较无显著性差异(P>0.05)。治疗组40例中有腹胀1例,口干1例,共有2例发生不良反应,不良反应率为5%。对照组39中腹胀3例,恶心、呕吐3例,共有6例发生不良反应,不良反应率为15.4%。两组不良反应率比较,差异有显著性(P<0.05)。结论:奥美拉唑、阿莫西林联合甲硝唑治疗幽门螺杆菌性溃疡疗效显著,不良反应小。
Objective: To investigate the efficacy and safety of omeprazole and amoxicillin combined with metronidazole in the treatment of Helicobacter pylori ulcer. Methods: From January 2010 to May 2011, 79 patients with peptic ulcer were randomly divided into two groups, 40 cases in the treatment group and 39 cases in the control group. None of the two groups received bismuth and non-treatment before the treatment Steroid analgesics. The treatment group omeprazole 20mg, 2 times / day, sooner or later 1 oral; amoxicillin 0.5g, 3 times / day orally, taking 30 minutes before meals; metronidazole 0.4g, 2 times / day, treatment 1 week. The control group was given lansoprazole 30mg, clarithromycin 0.5g, levofloxacin 0.2g, were 2 times / day, course of treatment for 1 week. Results: After 4 weeks treatment, 40 cases of urease-dependent test and 14C-negative test in 37 cases of treatment group had Hp eradication rate of 92.5%, 39 cases of urease-dependent test and 34 cases of 14C-negative test, Hp eradication rate was 87.2%, the treatment group slightly higher efficacy than the control group, but there was no significant difference between the two groups Hp eradication rate (P> 0.05). In the treatment group, there were 1 case of bloating and 1 case of dry mouth. A total of 2 cases had adverse reactions with a rate of adverse reactions of 5%. In control group 39, 3 cases had abdominal distension, 3 cases had nausea and vomiting, and 6 cases had adverse reactions with adverse reaction rate of 15.4%. Adverse reactions between the two groups, the difference was significant (P <0.05). Conclusion: Omeprazole, amoxicillin combined with metronidazole in the treatment of Helicobacter pylori ulceration have significant curative effect and small adverse reactions.