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目的了解我国不同地区HBsAg快检阴性献血者的HBV流行率、新发率,以综合评估HBV在献血者中的流行情况。方法收集2008年1月-2010年12月昆明、乌鲁木齐、洛阳和柳州4地血站720 885(人)次献血者人口统计学资料、2轮第3代ELISA HBs Ag初筛和确证数据,分别计算初次献血者和重复献血者的HBV流行率,利用文献报道的新发率评估模型,评估重复献血者的新发率。结果 3年间本组4地献血者HBV流行率:0.35%(1 518/435 786)(初次献血者)/0.014%(77/285 099)(重复献血者),其中昆明为0.24%(454/187 540)/0.015%(24/163640)、乌鲁木齐0.52%(463/89 309)/0.022%(22/100 208)、洛阳0.18%(171/94 654)/0.009%(15/175 797)、柳州0.67%(430/64 283)/0.013%(16/124 282);4地重复献血者中的HBV感染总体新发率为1.24‰。结论 4地献血者具有较高的HBV新发率,需采用更灵敏的第4代ELISA试剂和核酸检测,降低4地HBV对血液安全的影响。
Objective To understand the prevalence and new incidence of HBV in HBsAg negative blood donors in different areas in China so as to comprehensively evaluate the prevalence of HBV in blood donors. Methods The demographic data of 720 885 blood donors from four blood stations of Kunming, Urumqi, Luoyang and Liuzhou from January 2008 to December 2010 were collected. The data of the first three generations of ELISA HBsAg screening and confirmatory data The prevalence of HBV in primary blood donors and repeat donors was calculated, and the new incidence rate reported in the literature was used to evaluate the new incidence of repeated blood donors. Results The prevalence of HBV in 4 blood donors was 0.35% (1 518/435 786) (primary blood donors) / 0.014% (77/285 099) (repeat donors) in 3 years. Among them, Kunming was 0.24% (454 / (P06), Urumqi 0.52% (463/89 309) /0.022% (22/100 208), Luoyang 0.18% (171/94 654) /0.009% (15/175 797) Liuzhou 0.67% (430/64 283) /0.013% (16/124 282). The overall new infection rate of HBV infection in four repeat donors was 1.24 ‰. CONCLUSIONS: Four blood donors have a high incidence of HBV infection, and the more sensitive 4th generation ELISA reagents and nucleic acid tests should be used to reduce the impact of 4 HBV on blood safety.