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目的 探索巴戟天醇提物的抗抑郁作用。方法 采用大小鼠强迫性游泳和大鼠低速率差式强化程序 (DRL 72s)法。结果 在小鼠强迫性游泳模型上 ,po醇提物 2 0 0～ 40 0mg·kg- 1 ,或醇提物A 5 0mg·kg- 1 ,与ip地昔帕明 10mg·kg- 1 的作用类似 ,明显缩短小鼠的不动时间 ;同样 ,po醇提物 5 0～ 15 0mg·kg- 1 或醇提物A 2 5mg·kg- 1 也显著缩短大鼠强迫性游泳的不动时间 ,po地昔帕明 40mg·kg- 1 也有类似的效果。另外 ,在大鼠DRL 72s模型上 ,ip醇提物 10 0mg·kg- 1 或醇提物A 2 0mg·kg- 1 ,显著增加大鼠的强化数 ,其效应与ip地昔帕明 5mg·kg- 1 的相当 ,并显示明显的剂量依赖性。但与此同时 ,醇提物和醇提物A并不影响大鼠的反应数和效应比率。结论 巴戟天醇提物也同样具有抗抑郁作用
Objective To explore the antidepressant effect of Morinda officinalis extract. Methods Forced swimming in rats and rat low-rate differential enhancement (DRL 72s) were used. RESULTS: In the forced swimming model of mice, the alcohol extract of 200-400 mg/kg po, or the alcohol extract A 50 mg/kg, was associated with ip desipramine 10 mg/kg-1. Similarly, the immobility time of mice was significantly shortened; similarly, 50 to 150 mg·kg-1 or alcohol extract A 25 mg·kg-1 of po alcohol extract also significantly shortened the immobility time of compulsive swimming in rats. Podiamipramine 40 mg·kg-1 also had a similar effect. In addition, on the rat DRL 72s model, the ip alcohol extract 100 mg·kg -1 or alcohol extract A 20 mg·kg - 1 significantly increased the number of rat fortification, and its effect was similar to that of ip desipramine 5 mg. The kg-1 is comparable and shows a significant dose-dependence. At the same time, however, the alcohol extract and alcohol extract A did not affect the rat’s response and effect ratio. Conclusion Morinda officinalis extract also has antidepressant effect