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目的探讨前列腺癌患者粒子植入治疗后血清PSA变化规律。方法前列腺癌患者13例。临床分期：T_(1c)N_0M_0 8例,T_(2a)N_0M_0 5例；Gleason评分：5分4例,6分9例；血清PSA 2.8～14.6 ng/ml,平均8.2 ng/ml。采用~(125)I粒子植入治疗,治疗剂量D_(90)为140～155 Gy。术后定期复查血清PSA,观察其变化规律。结果13例患者随访3～23个月。术后1、2、3、6、9、12、15、18及21个月血清PSA中位值为6.7、5.0、2.7、1.6、1.2、0.9、0.8、0.8及0.7 ng/ml。分别为术前血清PSA中位数的72%、51%、29%、20%、13%、11%、9%、9%及8%。术后1个月30%患者血清PSA有波动。结论前列腺癌粒子植入治疗后患者血清PSA下降缓慢,早期有波动。术后1年尤其术后3个月内血清PSA下降相对较快。
Objective To investigate the changes of serum PSA in patients with prostate cancer after particle implantation. Methods Thirteen patients with prostate cancer. Clinical stage: T_ (1c) N_0M_0 8 cases, T_ (2a) N_0M_0 5 cases; Gleason score 5 points in 4 cases, 6 points and 9 cases; serum PSA 2.8 ~ 14.6 ng / ml, with an average of 8.2 ng / ml. With 125 I seed implantation, the therapeutic dose D 90 was 140 155 Gy. Postoperative serum PSA was regularly reviewed to observe the changes. Results 13 patients were followed up for 3 to 23 months. Serum PSA values were 6.7, 5.0, 2.7, 1.6, 1.2, 0.9, 0.8, 0.8 and 0.7 ng / ml at 1, 2, 3, 6, 9, 12, 15, 18 and 21 months postoperatively. They were 72%, 51%, 29%, 20%, 13%, 11%, 9%, 9% and 8% of the preoperative serum PSA, respectively. Serum PSA fluctuated in 30% of patients at 1 month after surgery. Conclusion Serum PSA decreased slowly and fluctuated in the early stage after the implantation of prostate cancer. Postoperative one year especially after 3 months of serum PSA decreased relatively fast.