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目的探讨糖尿病患者膀胱残余尿(bladder residual urine,BRU)增多的可能原因和临床意义。方法将所有住院糖尿病(DM)患者在B超下检测排除前列腺肥大和泌尿系统结石,之后分为BRU组(BRU≥50ml)和非膀胱残余尿组(NBRU组,BRU<50 ml)。比较两组患者的年龄、DM病程、肾功能变化和腓总神经传导速度(PNCV)以及尿白细胞排泄率(ULER),探讨BRU组患者BRU与PNCV和ULER的相互关系。结果 DM患者中BRU增多的发生率为33.42%,BRU组患者的年龄,DM病程、HbA1c血清尿素氮(BUN)和肌酐(SCr)及ULER明显高于NBRU组(P<0.05),而其PNCV和男/女比值则明显低于NBRU组(P<0.02)。BRU组患者中,BRU的增多与ULER正相关,而与PNCV呈负相关(r分别为0.152-、0.179;P分别<0.05、0.025。结论以BRU增多为主要表现的糖尿病神经原膀胱DNB患者以女性多见,在某种程度上可反映DM患者的周围神经损害,BRU的增多增加了DM患者尿道感染的发生率,应及早发现和消除DM患者的BRU。
Objective To investigate the possible causes and clinical significance of the increase of bladder residual urine (BRU) in diabetic patients. Methods All patients with in-hospital diabetes (DM) were excluded from benign prostatic hypertrophy and urolithiasis by B-ultrasound. They were divided into BRU group (BRU≥50ml) and non-bladder residual urine group (BRU <50ml). To investigate the relationship between BRU, PNCV and ULER in patients with BRU. The age, DM course, renal function, PNCV and urinary leukocyte excretion rate (ULER) were compared between the two groups. Results The incidence of BRU increased in DM patients was 33.42%. The age, DM duration, serum urea nitrogen (BUN), creatinine (SCr) and ULER in HbA1c group were significantly higher than those in NBRU group (P <0.05) And male / female ratio was significantly lower than the NBRU group (P <0.02). In BRU group, the increase of BRU was positively correlated with ULER and negatively correlated with PNCV (r = 0.152-, 0.179, respectively, P <0.05, 0.025, respectively) .Conclusions The patients with diabetic neuroblastoma with predominant BRU Female more common, to some extent, can reflect the peripheral nerve damage in patients with DM, increased BRU increased the incidence of urinary tract infection in DM patients should be detected and early detection and elimination of DM patients with BRU.