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目的观察芬太尼透皮贴剂的临床疗效、药物不良反应情况及安全性。方法对63例中重度癌痛患者使用芬太尼贴剂的疗效、疼痛缓解度、不良反应及生活质量进行观察评定。结果使用芬太尼贴剂治疗中重度癌痛镇痛有效率为69.8%(44/63),24例(38.1%)出现不良反应,与用药前比较患者生活质量显著改善,食欲、精神、睡眠、疲乏、情绪、日常生活、面部表情指标得到显著改善(P均<0.05)。结论芬太尼治疗晚期癌痛患者具有止痛作用显著、不良反应轻微的优势,是改善癌痛患者生活质量的有效办法。
Objective To observe the clinical efficacy, adverse reactions and safety of fentanyl transdermal patch. Methods The efficacy, pain relief, adverse reactions and quality of life of 63 patients with moderate-to-severe cancer pain treated with fentanyl patch were observed and evaluated. Results The effective rate of fentanyl patches was 69.8% (44/63) and 24 (38.1%) were adverse reactions. The quality of life was significantly improved compared with that before treatment. The appetite, mental, sleep , Fatigue, emotion, daily life and facial expression were significantly improved (all P <0.05). Conclusion Fentanyl treatment of patients with advanced cancer pain has a significant analgesic effect, slight adverse reactions, is an effective way to improve the quality of life of patients with cancer pain.