【摘 要】
：
Following cell death, DNA can be released into the blood plasma and other body fluids in the form of cell-free DNA (cfDNA). These DNA fragments are typically ～167 bp in length, corresponding to the length of DNA wrapped around one nucleosome core (147 bp)
【机 构】
：
Brain and Mind Center,School of Medical Sciences,Department of Neuroscience,The University of Sydney
论文部分内容阅读
Following cell death, DNA can be released into the blood plasma and other body fluids in the form of cell-free DNA (cfDNA). These DNA fragments are typically ～167 bp in length, corresponding to the length of DNA wrapped around one nucleosome core (147 bp), plus DNA tails that survive endogenous DNase digestion (～10 bp). CfDNA is derived from a variety of sources, each having unique diagnostic applications.
其他文献
Injuries to the central nervous system (CNS) such as stroke, brain, and spinal cord trauma often result in permanent disabilities because adult CNS neurons only exhibit limited axon regeneration. The brain has a surprising intrinsic capability of recoveri
Diabetic neuropathy is a prevalent microvascular complication of diabetes mellitus, affecting nerves in all parts of the body including corneal nerves and peripheral nervous system, leading to diabetic corneal neuropathy and diabetic peripheral neuropathy
Age-dependent protein-conformational diseases (PCDs), such as Alzheimer\'s disease (AD), Parkinson\'s disease (PD), or amyotrophic lateral sclerosis (ALS), are characterized by misfolding and aggregation of metastable proteins present within the prote
Traumatic brain injury (TBI) is a serious condition in which trauma to the head causes damage to the brain, leading to a disruption in brain function. This is a significant health issue worldwide, with around 69 million people suffering from TBI each year
The application of autologous fat grafting in reconstructive surgery is commonly used to improve functional form. This review aims to provide an overview of the scientific evidence on the biology of adipose tissue, the role of adipose-derived stem cells,
Despite the spontaneous regenerative capacity of the peripheral nervous system, clinical nerve repair often results in poor functional recovery with the high socio-economic burden. In presence of peripheral nerve injuries and when distal nerve transfers a
Alzheimer\'s disease (AD) constitutes the largest proportion of dementia worldwide, with a significant associated medical burden. The major pathological hallmarks of AD include the gradual accumulation and deposition of amyloid-beta (Aβ) plaques and hyp
The role of adult neural stem cells (NSCs) in demyelinating diseases of the central nervous system (CNS): Multipotent NSCs hold great potential for cell replacement in diseases and upon injury of the CNS. Originating from radial glial cells during nervous
Glutamate is the main excitatory neurotransmitter in the brain and binds to two major classes of receptors, the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and the N-methyl-D-aspartate (NMDA) receptors. Unlike AMPA receptors that are imme
Alzheimer\'s disease key facts: Alzheimer\'s disease (AD) is a slowly progressive neurodegenerative disease with no available effective treatment. It is possible to distinguish an early-onset AD that affects a limited number of subjects of young age,