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目的：探讨接受联合化疗的恶性肿瘤患者在中性粒细胞缺乏期感染的发生情况及相关因素。方法：１０４ 例接受联合化疗患者在中性粒细胞缺乏期分别采用综合措施，即层流室隔离，预防性应用抗生素、ＧＭ－ＣＳＦ激活骨髓等，单用抗生素防治，两组病例均为５２ 例。结果：综合组中性粒细胞恢复快，粒细胞缺乏期明显缩短，仍有８ 例发生感染，感染率１５．４％ ，但程度轻，预后好，无霉菌感染；单用抗生素组１４ 例发生感染，感染率２６．９％ ， Ｐ＞ ０．０５，差异无显著性，２ 例合并霉菌感染，死亡２例。结论：综合措施防治联合化疗中性粒细胞缺乏期感染是有效的。
Objective: To investigate the occurrence of neutropenia infection and related factors in patients with malignant tumors receiving combination chemotherapy. METHODS: A total of 104 patients who received combination chemotherapy were given comprehensive measures in the neutropenia phase, ie, laminar flow compartment isolation, prophylactic antibiotics, GM-CSF activation of bone marrow, etc., antibiotic treatment alone, 52 cases in both groups. . Results: The neutrophil recovery in the comprehensive group was rapid, and the agranulocytosis period was significantly shortened. There were still 8 cases of infection, the infection rate was 15.4%, but the degree was mild, the prognosis was good, there was no fungal infection; 14 cases occurred with the single antibiotic group. Infection, the infection rate was 26.9%, P> 0.05, the difference was not significant, 2 cases of fungal infection, and 2 deaths. Conclusion: Comprehensive measures to prevent and treat neutropenia infection in combination with chemotherapy are effective.