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组织胞浆菌病(Histoplasmosis)是西半球主要的地方性真菌病之一。该病在动物宿主中的早期暴露标志是迟发型超敏反应,这与保护性免疫相关。如果这种细胞介导的免疫不能控制感染,荚膜组织胞浆菌可经血行传播引起局部或播散性疾病,后者与婴儿期和免疫抑制状态(包括艾滋病)有关。据早期临床报道,在艾滋病相关的机会性感染时可发生真菌感染,截至1988年6月,报告艾滋病并发组织胞浆菌病的病例达80例以上。虽然一些研究资料不太完整,但
Histoplasmosis is one of the major endemic mycosis in the western hemisphere. Early signs of disease in animal hosts are marked by delayed-type hypersensitivity, which is associated with protective immunity. If this cell-mediated immunity does not control the infection, capsular histoplasmosis can spread by bloodstream causing local or disseminated disease, the latter associated with infancy and immunosuppressed states, including AIDS. According to earlier clinical reports, fungal infections can occur during AIDS-related opportunistic infections. As of June 1988, more than 80 cases of HIV-associated histoplasmosis have been reported. Although some research information is not complete,