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目前作为成人和新生儿疾病最常见病原菌的 B 族链球菌(GBS),引起了人们的瞩目。GBS 对于新生儿尤其危险,其感染的临床症状常重笃,脓毒症和脑膜炎的死亡率高达25%～75%。在 GBS 所致疾病的治疗上,苄青霉素是主要药物。然而,有人报道苄青霉素的疗效欠佳,甚至有的患者疾病复发。McGeary 的经验表明,无论是抗菌活性与苄青霉素相似的,还是较强或较弱的β-内酰胺类抗生素,也是有效药物。病原菌对抗菌药物敏感性的测定,是提高疗效和进行合理化疗的重要措施。本文的目的是深入地研究自新生儿及其母亲,以及自产院工作人员分离的GBS 对抗生素的敏感性。
Currently, Streptococcus group B (GBS), the most common pathogen of adult and neonatal diseases, has attracted much attention. GBS is particularly dangerous to newborns. Its clinical manifestations are often doubled, and sepsis and meningitis have a mortality rate of 25% -75%. In the treatment of diseases caused by GBS, penicillin is the main drug. However, it was reported that the efficacy of benzylpenicillin poor, and even some patients with disease recurrence. McGeary’s experience shows that both the stronger and the weaker β-lactam antibiotics, similar in antibacterial activity to penicillin, are also effective drugs. The determination of antimicrobial susceptibility of pathogenic bacteria is an important measure to improve the curative effect and to carry out reasonable chemotherapy. The purpose of this article is to study in depth the susceptibility of GBS to antibiotics isolated from newborns and their mothers and from home-workers.