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目的:总结系统性红斑狼疮(SLE)并弥漫性肺泡出血(DAH)的临床特点。方法:回顾性分析2002年1月-2012年1月我院SLE并DAH患者17例的临床资料。结果:SLE并DAH的发病率为1.3%(17/2235;女性16例,SLEDAI评分平均(14.1±3.2)分;常见症状为发热、呼吸困难、咳血;患者接受积极抗感染、大剂量激素、免疫抑制剂及丙种球蛋白治疗,死亡率为59%(10/17)。结论:DAH是SLE的少见并发症,好发女性,多发生于SLE活动期,常合并严重肺部感染,死亡率高。
Objective: To summarize the clinical features of systemic lupus erythematosus (SLE) and diffuse alveolar hemorrhage (DAH). Methods: The clinical data of 17 patients with SLE and DAH in our hospital from January 2002 to January 2012 were retrospectively analyzed. Results: The incidence of SLE and DAH was 1.3% (17/2235; 16 women and 14.1 ± 3.2) SLEDAI. The common symptoms were fever, dyspnea and hemoptysis. Patients received active anti-infective and high-dose hormones , Immunosuppressive agents and gammaglobulin treatment, the mortality rate was 59% (10/17) .Conclusion: DAH is a rare complication of SLE, predilection women, mostly in the active stage of SLE, often associated with severe pulmonary infection and death High rate.