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目的探讨脑梗死患者发病过程中C反应蛋白(CRP)、纤维蛋白原(FIB)及血小板(PLT)计数、平均血小板体积(MPV)、血小板分布宽度(PDW)的意义与梗死面积的相关性。方法检测47例脑梗死患者和40例健康对照者血清中CRP、FIB、PLT、PDW、MPV的含量。结果梗死急性期MPV明显增高(P<0.05);CRP、FIB、PDW显著增高(P<0.01);PLT显著降低(P<0.01)。结论CRP、FIB、MPV、PDW的变化值随梗死面积的增加而增加,PLT则随梗死面积的增加而减少。
Objective To investigate the correlation between the significance of C-reactive protein (CRP), fibrinogen (FIB) and platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) Methods Serum levels of CRP, FIB, PLT, PDW and MPV were measured in 47 patients with cerebral infarction and 40 healthy controls. Results MPV was significantly increased in the acute stage of infarction (P <0.05), CRP, FIB and PDW were significantly increased (P <0.01), PLT was significantly decreased (P <0.01). Conclusion The changes of CRP, FIB, MPV and PDW increase with the increase of infarct size, but PLT decrease with the increase of infarct size.