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目的:探讨单纯性颅脑创伤（isolated traumatic brain injury, iTBI）患者早期并发心脏收缩功能不全的相关因素，评估并发心脏收缩功能不全对iTBI患者预后的影响。方法:纳入苏州大学附属第一医院急诊创伤中心2017年1月至2018年10月收治的123例中、重度iTBI患者,排除既往有心血管系统疾病患者。入院后24 h内采用经胸超声心动图评估心脏左室收缩功能。依据超声心动图检查结果将患者分为心脏收缩功能正常组（n n=100）和收缩功能不全组（n n=23）。收集所有患者入院时GCS评分、收缩压、心率、高敏肌钙蛋白T（high-sensitivity cardiac troponin T，hs-cTnT），以及临床治疗变量（镇静药物、血管活性药的使用等）、是否行开颅手术治疗、住院期间临床结局（生存或死亡）等资料。采用Logistic回归分析影响患者并发心脏收缩功能不全的相关因素，绘制受试者工作曲线（ROC曲线）评估各指标对iTBI患者并发心功能不全的预测价值。n 结果:收缩功能不全组入院时收缩压（147.3±23.3）mmHg、心率（96.1±26.3）次/min、hs-cTnT（16.48±8.17）pg/mL，均高于收缩功能正常组（n P<0.05），收缩功能不全组GCS评分低于收缩功能正常组（n P<0.05）。Logistic回归分析显示，入院时心率（n OR=1.129，95％n CI：1.001~1.516，n P=0.038）、GCS评分（n OR=0.640，95%n CI：0.445~0.920，n P=0.016）、hs-cTnT（n OR=1.054，95%n CI：1.009~1.101，n P=0.002）是iTBI患者并发心脏收缩功能不全的独立危险因素。入院时hs-cTnT的ROC曲线下面积最大（AUC=0.863，n P<0.01）。心脏收缩功能不全组患者住院期间病死率高于收缩功能正常组（52.5% n vs 22%，P=0.004）。n 结论:入院时心率、GCS评分、血清超敏肌钙蛋白T是iTBI患者病发心脏收缩功能不全的独立危险因素。血清hs-cTnT能够较好地预测心功能不全的发生，并发心功能不全iTBI患者住院期间病死率更高。早期发现并及时干预可能有利于改善患者预后。“,”Objective:To investigate the risk factors of systolic dysfunction early complicated in patients with isolated traumatic brain injury (iTBI) and to evaluate the influence of complicated systolic dysfunction on the prognosis of iTBI patients.Methods:From January 2017 to October 2018, 123 patients with moderate or severe iTBI admitted to Trauma Centre in our hospital were included in the study, and patients with previous cardiovascular diseases were excluded. Left ventricular systolic function was assessed by transthoracic echocardiography within 24 h after admission. The patients were divided into normal systolic function group (n n=100) and systolic dysfunction group (n n=23) according to the results of echocardiography. Data were collected from all patients on admission, including GCS score, systolic blood pressure, heart rate, high-sensitivity cardiac troponin T (hs-cTnT), clinical treatment variables (use of sedative drugs, vasoactive drugs, etc.), craniotomy or not and clinical outcomes (survival or death) during hospitalization. Logistic regression analysis was used to analyze the related factors for iTBI patients complicated with systolic dysfunction, and receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of each index for iTBI patients complicated with cardiac insufficiency.n Results:The systolic blood pressure (147.3±23.3) mmHg, the heart rate (96.1±26.3) beats/min and the hs-cTnT level (16.48±8.17) pg/mL in the systolic dysfunction group were higher than those in the normal systolic function group on admission (all n P<0.05); and the GCS score in the systolic dysfunction group was lower than that in the normal systolic function group (n P<0.05). Logistic regression analysis showed that the heart rate (n OR=1.129, 95%n CI: 1.001-1.516; n P=0.038), the GCS score (n OR=0.640, 95%n CI: 0.445-0.920; n P=0.016) and the hs-cTnT level (n OR=1.054, 95%n CI: 1.009-1.101; n P=0.002) on admission were independent risk factors for iTBI patients complicated with systolic dysfunction. The area under the ROC curve (AUC) of the hs-cTnT levelon admission was the largest (AUC=0.863, n P<0.01). The in-hospital mortality of patients in the systolic dysfunction group was higher than that of patients in the normal systolic function group (52.5% n vs 22%, P=0.004).n Conclusions:The heart rate, the GCS score and the serum hs-cTnT level on admission were independent risk factors for iTBI patients complicated with systolic dysfunction. The hs-cTnT level could better predict the occurrence of cardiac systolic dysfuncion, and higher in-hospital mortality was found in iTBI patients complicated with systolic dysfunction. Therefore, early detection and timely intervention may improve the prognosis of these patients.