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应用放射免疫分析法（ＲＬＡ）对３２例结核性脑膜炎（ＴＢＭ）患者脑脊液和血浆中内皮素（ＥＴ）含量进行动态测定。结果表明：ＴＢＭ患者脑脊液及血浆ＥＴ含量均明显高于对照组（Ｐ＜０．０１），ＥＴ含量随正规抗结核治疗时间延长而逐渐下降，３个月后接近健康人ＥＴ含量（Ｐ＞０．０５）。正规抗结核治疗时间与脑脊液及血浆ＥＴ含量呈负相关关系（Ｐ＜０．０５）。对ＥＴ在ＴＢＭ病损机制中的作用进行了讨论。
The content of endothelin (ET) in cerebrospinal fluid and plasma of 32 patients with tuberculous meningitis (TBM) was measured by radioimmunoassay (RLA). The results showed that the content of ET in cerebrospinal fluid and plasma of patients with TBM was significantly higher than that of the control group (P <0.01). The content of ET decreased gradually with the prolongation of regular anti-TB treatment, and was close to that of healthy people after 3 months .05). The duration of regular anti-TB treatment was negatively correlated with plasma ET content (P <0.05). The role of ET in the pathogenesis of TBM is discussed.