高血压是最常见的慢性非传染性疾病,具有“三高”——高患病率、高致残率、高死亡率,“三低”——低知晓率、低控制率、低治愈率的特点。其中,低控制率是阻碍高血压降压达标的关键因素。目前,高血压多采用联合疗法实现有效降压,本文就高血压低剂量联合疗法的相关研究进行了综述,特别提出了药物四分之一剂量治疗(Quadpill)这一新概念,即:分别取A、B、C、D(尤指噻嗪类)四类降压药标准剂量的四分之一,联合制成一枚复方药丸,作为高血压的初始治疗方案。鉴于四分之一剂量四联降压疗法可以在保证最优降压效果的同时降低不良反应的发生率,故未来将成为高血压防治策略的新趋势。 Hypertension is the most common chronic noncommunicable disease with a high prevalence of morbidity, high morbidity, high mortality, low blood pressure, low awareness, and low control rates , Low cure rate characteristics. Among them, the low control rate is hindering the key factor of blood pressure compliance. At present, hypertension is more commonly used combination therapy to achieve effective antihypertensive, this article on hypertension combined with low-dose therapies are reviewed, in particular, proposed a quarter dose of the drug (Quadpill) this new concept, namely: A, B, C, D (especially thiazide) four classes of antihypertensive drugs a quarter of the standard dose, a combination of a compound pill, as the initial treatment of hypertension. Given the quarter dose of quadruple antihypertensive therapy can ensure the optimal antihypertensive effect while reducing the incidence of adverse reactions, so the future will become the new trend of prevention and treatment of hypertension.