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用利血平、东莨菪碱、亚硝酸钠复制小鼠记忆障碍模型 ,应用Y型电迷宫和跳台法测定模型动物的记忆能力 ,同时观察该药对脑组织单胺类神经递质、胆碱酯酶活性的影响。结果表明 ,通脉益智胶囊能提高小鼠的记忆能力 ,提高记忆的正确率 ,减少错误次数 ,延长潜伏期时间 ,缩短跑至安全区时间。还能调节单胺类神经递质含量 ,降低胆碱酯酶活性 ,提示其作用机理可能与改善脑组织胆碱能神经和肾上腺素能神经功能、抑制胆碱酯酶活性有关。
The model of memory impairment in mice was reproduced by reserpine, scopolamine and sodium nitrite. The memory abilities of model animals were determined by Y-type electric maze and step-down method. The monoamine neurotransmitters and cholinesterase in the brain were observed. The effect of activity. The results showed that Tongmai Yizhi Capsule can improve mice’s memory ability, improve the correct rate of memory, reduce the number of errors, prolong the incubation period, and shorten the time to run to the safe area. It can also regulate the content of monoamine neurotransmitters and decrease the activity of cholinesterase, suggesting that the mechanism of action may be related to the improvement of cholinergic nerve and adrenergic nerve function in the brain and inhibition of cholinesterase activity.