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The hone marrow puncture fluid of human multiple myeloma was inoculated subcutaneously in BALB/C/nu nude mice. After passage of the xenograft from nude mice in vitro, a murine malignant lymphosarcoma cell line was unexpectedly established, which was named NLB-SK. The murine NLBSK cell line has been cultivated in vitro over 72 passages for 10 months. Repeated cryopreservation showed that the murine NLB-SK cell line revived satisfactorily. Based on cell biological characteristics the malignant transformation migh the attributed to horizontal oncogenesis between human malignant tumor cells and nude mouse normal somatic cells.
The hone marrow puncture fluid of human multiple myeloma was inoculated subcutaneously in BALB / C / nu nude mice. After passage of the xenograft from nude mice in vitro, a murine malignant lymphosarcoma cell line was unexpectedly established, which was named NLB-SK. The Based on cell biological characteristics the malignant transformation migh the attributed to horizontal oncogenesis between human malignant tumor cells and nude mouse normal somatic cells.