论文部分内容阅读
在等降压剂量下吡那地尔（ＰＩＮ，２ｍｇ·ｋｇ－１·ｄ－１，ｉｇ）和赖诺普利（ＬＩＳ，１２ｍｇ·ｋｇ－１·ｄ－１，ｉｇ）可使４月龄自发性高血压大鼠（ＳＨＲ）的血压下降６．０～８．０ｋＰａ，并接近同种属正常血压大鼠的血压水平。ＰＩＮ治疗３０ｄ后对ＳＨＲ左室肥厚无明显作用，既不加重，也不减轻；对心脏舒张功能无明显影响，但有增强收缩功能的趋势。ＬＩＳ治疗３０ｄ后，ＳＨＲ心脏重量与体重之比有下降趋势，其心脏显著小于未治疗对照组，ＬＩＳ可减轻左室肥厚。而ＬＩＳ对心脏舒缩功能均无明显影响。ＰＩＮ和ＬＩＳ均降低主动脉射血量而不影响冠脉血流量。结果表明，ＰＩＮ既不加重也不逆转左室肥厚，ＬＩＳ可减轻左室肥厚，二者对心脏功能重构影响不明显
Pinacidil (PIN, 2 mg · kg-1 · d-1, ig) and lisinopril (LIS, 12 mg · kg-1 · d-1, ig) Spontaneous hypertensive rats (SHR) blood pressure decreased 6.0 ~ 8.0kPa, and close to the same kind of normal blood pressure in rats. PIN treatment of SHD after left ventricular hypertrophy had no significant effect, neither exacerbated nor alleviated; no significant effect on diastolic function, but there is a tendency to enhance systolic function. After 30 days of LIS treatment, the ratio of heart weight to body weight of SHR had a decreasing trend, and its heart was significantly smaller than that of untreated control group. LIS could reduce left ventricular hypertrophy. However, LIS had no significant effect on cardiac systolic and diastolic function. Both PIN and LIS decreased aortic ejection without affecting coronary flow. The results showed that PIN neither aggravate nor reverse left ventricular hypertrophy, LIS can reduce left ventricular hypertrophy, the two have no significant effect on cardiac remodeling