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在离体灌流的牛蛙交感神经节标本上，电刺激节前纤维，细胞内记录Ｂ细胞的电活动，观察给予皮质醇对Ｂ细胞突触传递的快速作用。主要结果有：（１）电刺激节前纤维，细胞内记录１７０个Ｂ细胞的动作电位，给予皮质醇后０５～３ｍｉｎ内，５２个Ｂ细胞的突触传递发生脱漏甚至完全阻断，有明显的量效关系。甾体激素胞内受体阻断剂ＲＵ３８４８６可部分阻断这种作用。（２）蛋白合成抑制剂放线菌酮不能阻断皮质醇的快速阻断作用。（３）阿托品阻断Ｍ受体后，皮质醇对Ｂ细胞突触传递的快速阻断作用增强。上述结果提示，皮质醇通过非基因组机制对牛蛙交感神经节Ｂ细胞的突触传递产生快速阻断作用。
In vitro perfusion of the bullfrog sympathetic ganglia specimens, electrical stimulation of preganglionic fibers, intracellular recording of B cell electrical activity observed cortisol on the B cell synaptic transmission of the rapid effect. The main results were as follows: (1) The pre-anapillary fibers were electrically stimulated and the action potentials of 170 B cells were recorded intracellularly. During the 05 ~ 3 min after cortisol administration, 52 B cells were exposed or even completely blocked by synaptic transmission, There is a significant dose-effect relationship. The steroid hormone intracellular receptor blocker RU38486 can partially block this effect. (2) Cycloheximide, a protein synthesis inhibitor, failed to block the rapid blockade of cortisol. (3) Atropine block M receptor, Cortisol on B cell synaptic transmission of rapid blockade increased. The above results suggest that cortisol has a rapid blocking effect on the synaptic transmission of B cells in the sympathetic ganglion of the frog through non-genomic mechanisms.