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目的:探讨抑木扶土法联合GP方案治疗晚期乳腺癌的临床疗效。方法:选取60例晚期乳腺癌患者,随机分为对照组及治疗组。两组均予GP方案治疗,治疗组再予抑木扶土中药治疗。观察两组治疗前后体力状况(KPS)、中医症状评分、生活质量的变化,以及治疗过程中毒副反应,评估其临床疗效。结果:对照组总有效率为50.0%,治疗组为56.7%,两组比较,差异无统计学意义(P>0.05)。治疗后两组患者KPS评分高于同组治疗前(P<0.05),而中医症状评分低于同组治疗前(P<0.05);治疗后治疗组患者KPS评分高于同期对照组(P<0.05),而中医症状评分低于同期对照组(P<0.05)。治疗后两组患者躯体功能、角色功能、情绪功能、认知功能、社会功能、总体健康状况评分均高于同组治疗前(P<0.05);治疗后治疗组躯体功能、情绪功能、社会功能、总体健康状况评分均高于同期对照组(P<0.05)。治疗后,两组患者均产生不同程度毒副反应,以损害患者WBC、N、PLT、HB、ALT、BUN、Cr为主;治疗后治疗组患者WBC、N、PLT、HB、ALT各指标损害总发生率均低于对照组(P<0.05)。结论:抑木扶土法联合GP方案治疗晚期乳腺癌,能有效改善患者临床症状,提高其生活质量,降低化疗过程中的毒副反应。
Objective: To investigate the clinical curative effect of the method of combining wood with furrow and GP to treat advanced breast cancer. Methods: Sixty patients with advanced breast cancer were selected and randomly divided into control group and treatment group. The two groups were treated with GP regimen, and the treatment group was treated with traditional Chinese medicine. Before and after treatment, the physical condition (KPS), symptom score of TCM, quality of life changes, and the side effects during treatment were observed to evaluate the clinical efficacy. Results: The total effective rate was 50.0% in the control group and 56.7% in the treatment group. There was no significant difference between the two groups (P> 0.05). After treatment, KPS scores of two groups were significantly higher than those of the same group before treatment (P <0.05), while symptom score of TCM was lower than that of the same group before treatment (P <0.05); KPS score of the treatment group was higher than that of the control group (P < 0.05), while TCM symptom scores were lower than the control group (P <0.05). After treatment, body function, role function, emotion function, cognitive function, social function and general health status score of the two groups were significantly higher than those before treatment (P <0.05); after treatment, physical, emotional and social functions , The overall health status scores were higher than the same period control group (P <0.05). After treatment, both groups of patients had different degrees of toxic and side effects, which would damage the WBC, N, PLT, HB, ALT, BUN and Cr in the two groups. The indexes of WBC, N, PLT, HB, The overall incidence was lower than the control group (P <0.05). CONCLUSION: The combination of kyphusha method and GP regimen in the treatment of advanced breast cancer can effectively improve the clinical symptoms, improve the quality of life and reduce the side effects of chemotherapy.