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用免疫组织化学方法研究了系统应用马桑内酯所致的慢性癫痫大鼠海马中星形胶质细胞的胶质纤维酸性蛋白的表达。结果证明，整个海马的胶质纤维酸性蛋白免疫反应明显增强，并可见阳性细胞增生、胞体肥大，尤以齿状回门区和海马分子腔隙层及始层为甚。此外，本实验还发现海马胶质纤维酸性蛋白的阳性反应强度随发作后不同时间间隔（２ ｈ～９ ｄ）而不同，且直至发作后９ ｄ，胶质纤维酸性蛋白阳性反应程度仍高于对照组。此结果表明，马桑内酯所致癫痫反复发作可使海马星形胶质细胞内胶质纤维酸性蛋白的表达长期保持在较高水平。
The expression of glial fibrillary acidic protein (GFAP) of astrocytes in the hippocampus of chronic epilepsy rats induced by docetaxel was systematically studied by immunohistochemistry. The results show that the glial fibrillary acidic protein in the whole immune response was significantly enhanced, and shows positive cell proliferation, cell body hypertrophy, especially in the dentate gyrus and hippocampal lacuna and lamellae even more. In addition, we also found that the positive reaction intensity of glial fibrillary acidic protein in hippocampus varied with time (2 h to 9 d) after the onset of attack, and the glial fibrillary acidic protein positive reaction was still higher than that of glial fibrillary acidic protein Control group. This result indicates that repeated episodes of epilepsy caused by the intraocular lactone can keep the expression of glial fibrillary acidic protein in hippocampus astrocytes for a long period of time.