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目的分析不同剂量氯胺酮对七氟烷麻醉下小儿分离焦虑及苏醒期躁动(emergence agitation,EA)的影响,为临床麻醉提供参考依据。方法将择期行疝修补术的患儿96例随机分为A、B、C、D 4组各24例,其中A组患儿给予生理盐水,B、C、D组分别在小儿入室前静脉滴注氯胺酮0.5mg/kg、0.75mg/kg、1mg/kg,所有患儿均采取七氟烷维持麻醉,对各组患儿麻醉诱导分离焦虑评分及苏醒期躁动情况进行统计分析。结果 B、C、D 3组患儿分离焦虑评分及躁动评分均较A组低,C组分离焦虑评分及躁动评分较B、D组低,差异均有统计学意义(P<0.05)。结论患儿入室前静脉滴注氯胺酮0.75mg/kg可减少小儿分离焦虑评分及躁动评分,值得临床推广应用。
Objective To analyze the effects of different doses of ketamine on acute anxiety and recovery agitation (EA) in children under sevoflurane anesthesia, and to provide a reference for clinical anesthesia. Methods 96 cases of children undergoing hernia repair were randomly divided into A, B, C and D 4 groups, 24 cases in each group, of which A group was given normal saline. Groups B, C and D were infused intravenously Ketamine 0.5mg / kg, 0.75mg / kg, 1mg / kg, all children were treated with sevoflurane anesthesia, anesthesia-induced anxiety in children with anxiety-induced anxiety scores and restlessness were statistically analyzed. Results The scores of anxiety and restlessness in groups B, C and D were lower than those in group A, and the scores of anxiety and restlessness in group C were lower than those in groups B and D (P <0.05). Conclusion In children with intravenous infusion of ketamine 0.75mg / kg intravenous injection can reduce anxiety and agitation score in children, worthy of clinical application.