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目的探讨人类博卡病毒(HBoV)所致细支气管炎的临床特点。方法收集因细支气管炎于2007年6月-2008年5月住院治疗的271例患儿的呼吸道标本(鼻咽分泌物或咽拭子),应用多重PCR技术检测其HBoV,呼吸道合胞病毒(RSV),腺病毒(ADV),鼻病毒(RhV),流感病毒A、B型(FluA、FluB),副流感病毒1、3型(PIV1、PIV3),人类偏肺病毒(hMPV)9种病毒。随机选取RSV感染阳性患儿28例作为对照组。分析HBoV感染组与对照组患儿的临床特点。结果271例标本中,病毒阳性标本163例(60.1%)。其中HBoV阳性21例(12.9%),RSV阳性61例(37.4%);HBoV并其他病毒感染8例(38.1%),与RSV、FluA合并感染各3例,与ADV、RhV合并感染各2例,与hMPV合并感染1例。HBoV感染组与对照组患儿临床资料除在流行季节上有差异外,在性别、发病年龄、临床症状、肺部体征、辅助检查、住院天数、病情严重程度方面比较均无差异。结论HBoV是小儿细支气管炎的另一重要病原体,与RSV感染者在临床表现上无明显差异。HBoV细支气管炎的临床症状较轻,呼吸功能均属于轻中度受损,且以轻度为主,均未出现并发症、重症病例或死亡病例。
Objective To investigate the clinical features of bronchiolitis caused by human Bocavirus (HBoV). Methods Respiratory specimens (nasopharyngeal secretions or throat swabs) from 271 children admitted to hospital for treatment of bronchiolitis from June 2007 to May 2008 were collected. Multiplex PCR was used to detect HBoV, respiratory syncytial virus 9 strains of viruses including RSV, ADV, RhV, influenza A, B (FluA, FluB), parainfluenza virus type 1 and 3 (PIV1 and PIV3) and human metapneumovirus . A total of 28 children with positive RSV infection were selected as control group. The clinical features of HBoV infection group and control group were analyzed. Results Of the 271 specimens, 163 were positive (60.1%). Among them, HBoV positive was found in 21 cases (12.9%) and RSV positive in 61 cases (37.4%). HBoV and other viruses were infected in 8 cases (38.1%), 3 cases were infected with RSV and FluA, 2 cases were infected with ADV and RhV , With hMPV infection in 1 case. The clinical data of HBoV infection group and control group had no significant difference in sex, age of onset, clinical symptoms, lung signs, auxiliary examination, days of hospitalization, and severity of illness, except for the epidemic season. Conclusion HBoV is another important pathogen of bronchiolitis in children. There is no significant difference in clinical manifestations between RSV and HBoV. HBoV bronchiolitis mild clinical symptoms, respiratory function are mild to moderate damage, and mild-based, no complications, severe cases or deaths.